Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer

Here we report that PTEN contributes to DNA double-strand break (DSB) repair via homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid assay, (ii) enhanced sensitivity to mitomycin-C or olaparib and (iii) reduced RAD51 loading at IR-induced DSBs upon PTEN knockdow...

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Detalles Bibliográficos
Autores principales: Mansour, W. Y., Tennstedt, P., Volquardsen, J., Oing, C., Kluth, M., Hube-Magg, C., Borgmann, K., Simon, R., Petersen, C., Dikomey, E., Rothkamm, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834544/
https://www.ncbi.nlm.nih.gov/pubmed/29500400
http://dx.doi.org/10.1038/s41598-018-22289-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834544/
https://www.ncbi.nlm.nih.gov/pubmed/29500400
http://dx.doi.org/10.1038/s41598-018-22289-7

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