Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress

Disruption of the insulin-PI3K-Akt signalling pathway in kidney podocytes causes endoplasmic reticulum (ER) stress, leading to podocyte apoptosis and proteinuria in diabetic nephropathy. We hypothesised that by improving insulin sensitivity we could protect podocytes from ER stress. Here we use esta...

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Detalles Bibliográficos
Autores principales: Garner, Kathryn L., Betin, Virginie M. S., Pinto, Vanda, Graham, Mark, Abgueguen, Emmanuelle, Barnes, Matt, Bedford, David C., McArdle, Craig A., Coward, Richard J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834602/
https://www.ncbi.nlm.nih.gov/pubmed/29500363
http://dx.doi.org/10.1038/s41598-018-22233-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834602/
https://www.ncbi.nlm.nih.gov/pubmed/29500363
http://dx.doi.org/10.1038/s41598-018-22233-9

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