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Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress
Disruption of the insulin-PI3K-Akt signalling pathway in kidney podocytes causes endoplasmic reticulum (ER) stress, leading to podocyte apoptosis and proteinuria in diabetic nephropathy. We hypothesised that by improving insulin sensitivity we could protect podocytes from ER stress. Here we use esta...
Autores principales: | Garner, Kathryn L., Betin, Virginie M. S., Pinto, Vanda, Graham, Mark, Abgueguen, Emmanuelle, Barnes, Matt, Bedford, David C., McArdle, Craig A., Coward, Richard J. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834602/ https://www.ncbi.nlm.nih.gov/pubmed/29500363 http://dx.doi.org/10.1038/s41598-018-22233-9 |
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