Simultaneous induction and blockade of autophagy by a single agent

Besides cell death, autophagy and cell senescence are the main outcomes of anticancer treatment. We demonstrate that tacrine-melatonin heterodimer C10, a potent anti-Alzheimer’s disease drug, has an antiproliferative effect on MCF-7 breast cancer cells. The main cell response to a 24 h-treatment wit...

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Detalles Bibliográficos
Autores principales: Kucharewicz, Karolina, Dudkowska, Magdalena, Zawadzka, Anna, Ogrodnik, Mikolaj, Szczepankiewicz, Andrzej A., Czarnocki, Zbigniew, Sikora, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834631/
https://www.ncbi.nlm.nih.gov/pubmed/29500364
http://dx.doi.org/10.1038/s41419-018-0383-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834631/
https://www.ncbi.nlm.nih.gov/pubmed/29500364
http://dx.doi.org/10.1038/s41419-018-0383-6

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