Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases

Huntington's disease (HD) is a progressive autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in the first exon of the huntingtin gene (HTT). The accumulation of polyglutamine-rich huntingtin proteins affects various cellular functions and causes selective dege...

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Detalles Bibliográficos
Autores principales: Dabrowska, Magdalena, Juzwa, Wojciech, Krzyzosiak, Wlodzimierz J., Olejniczak, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834764/
https://www.ncbi.nlm.nih.gov/pubmed/29535594
http://dx.doi.org/10.3389/fnins.2018.00075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834764/
https://www.ncbi.nlm.nih.gov/pubmed/29535594
http://dx.doi.org/10.3389/fnins.2018.00075

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