Acquired resistance of phosphatase and tensin homolog‐deficient cells to poly(ADP‐ribose) polymerase inhibitor and Ara‐C mediated by 53BP1 loss and SAMHD1 overexpression

With increasing uses of poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPi) for cancer therapy, understanding their resistance is becoming urgent. However, acquired PARPi resistance in the phosphatase and tensin homolog (PTEN)‐deficient background is poorly understood. We generated 3 PARPi‐resista...

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Detalles Bibliográficos
Autores principales: Wang, Yu‐Ting, Yuan, Bo, Chen, Hua‐Dong, Xu, Lin, Tian, Yu‐Nan, Zhang, Ao, He, Jin‐Xue, Miao, Ze‐Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834817/
https://www.ncbi.nlm.nih.gov/pubmed/29274141
http://dx.doi.org/10.1111/cas.13477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834817/
https://www.ncbi.nlm.nih.gov/pubmed/29274141
http://dx.doi.org/10.1111/cas.13477

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