Simulation Modeling to Compare High-Throughput, Low-Iteration Optimization Strategies for Metabolic Engineering

Increasing the final titer of a multi-gene metabolic pathway can be viewed as a multivariate optimization problem. While numerous multivariate optimization algorithms exist, few are specifically designed to accommodate the constraints posed by genetic engineering workflows. We present a strategy for...

Descripción completa

Detalles Bibliográficos
Autores principales: Heinsch, Stephen C., Das, Siba R., Smanski, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835107/
https://www.ncbi.nlm.nih.gov/pubmed/29535690
http://dx.doi.org/10.3389/fmicb.2018.00313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835107/
https://www.ncbi.nlm.nih.gov/pubmed/29535690
http://dx.doi.org/10.3389/fmicb.2018.00313

Ejemplares similares