Triple Vectors Expand AAV Transfer Capacity in the Retina

Retinal gene transfer with adeno-associated viral (AAV) vectors holds great promise for the treatment of inherited retinal degenerations (IRDs). One limit of AAV is its transfer capacity of about 5 kb, which can be expanded to about 9 kb, using dual AAV vectors. This strategy would still not suffice...

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Detalles Bibliográficos
Autores principales: Maddalena, Andrea, Tornabene, Patrizia, Tiberi, Paola, Minopoli, Renato, Manfredi, Anna, Mutarelli, Margherita, Rossi, Settimio, Simonelli, Francesca, Naggert, Jurgen K., Cacchiarelli, Davide, Auricchio, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835116/
https://www.ncbi.nlm.nih.gov/pubmed/29292161
http://dx.doi.org/10.1016/j.ymthe.2017.11.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835116/
https://www.ncbi.nlm.nih.gov/pubmed/29292161
http://dx.doi.org/10.1016/j.ymthe.2017.11.019

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