Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway

OBJECTIVE: Rheumatoid arthritis (RA) multidrug resistance is associated with P-glycoprotein (P-gp) overexpression. We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients wi...

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Detalles Bibliográficos
Autores principales: Qin, Kaili, Chen, Kailin, Zhao, Wenpeng, Zhao, Xiangcong, Luo, Jing, Wang, Qun, Gao, Chong, Li, Xiaofeng, Wang, Caihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835257/
https://www.ncbi.nlm.nih.gov/pubmed/29670920
http://dx.doi.org/10.1155/2018/3619320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835257/
https://www.ncbi.nlm.nih.gov/pubmed/29670920
http://dx.doi.org/10.1155/2018/3619320

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