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Long‐term programming effects on blood pressure following gestational exposure to the I (Kr) blocker Dofetilide

A slow embryonic heart rate in early‐mid gestation is associated with increased risk of embryonic death and malformation, however, the long‐term consequences remain unknown. We administered Dofetilide (Dof, 2.5 mg/kg), a drug that produces embryo‐specific bradycardia, to pregnant rats from gestation...

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Detalles Bibliográficos
Autores principales: Prestipino, Louise, Polson, Jaimie W., Brolin, Elisabeth, Ritchie, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835481/
https://www.ncbi.nlm.nih.gov/pubmed/29504284
http://dx.doi.org/10.14814/phy2.13621