Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of Zebrafish

A TIE2 mutation causing arginine-to-tryptophan substitution at residue 849 (TIE2-R849W) is commonly identified in heredofamilial venous malformation. However, there is no in vivo model to confirm the pathogenic role of TIE2-R849W. Humanized TIE2-R849W plasmid was constructed via PCR-mediated site-di...

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Detalles Bibliográficos
Autores principales: Du, Zhong, Ma, Hai-Long, Zhang, Zhi-Yuan, Zheng, Jia-Wei, Wang, Yan-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835709/
https://www.ncbi.nlm.nih.gov/pubmed/29511374
http://dx.doi.org/10.7150/ijms.23054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835709/
https://www.ncbi.nlm.nih.gov/pubmed/29511374
http://dx.doi.org/10.7150/ijms.23054

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