A computational study for rational HIV-1 non-nucleoside reverse transcriptase inhibitor selection and the discovery of novel allosteric pockets for inhibitor design

HIV drug resistant mutations that render the current Highly Active Anti-Retroviral Therapy (HAART) cocktail drugs ineffective are increasingly reported. To study the mechanisms of these mutations in conferring drug resistance, we computationally analyzed 14 reverse transcriptase (RT) structures of H...

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Detalles Bibliográficos
Autores principales: Chiang, Ron Zhi-Hui, Gan, Samuel Ken-En, Su, Chinh Tran-To
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835713/
https://www.ncbi.nlm.nih.gov/pubmed/29437904
http://dx.doi.org/10.1042/BSR20171113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835713/
https://www.ncbi.nlm.nih.gov/pubmed/29437904
http://dx.doi.org/10.1042/BSR20171113

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