Cargando…

LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2

The ‘Warburg effect’ is considered a vital hallmark of cancer cells, characterized by an altered metabolism, in which cells rely on aerobic glycolysis. As a key enzyme of aerobic glycolysis, pyruvate kinase M2 (PKM2) serves a crucial role in tumorigenesis. Accumulating studies have indicated that PK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Jian, Chen, Min, Gao, Sumeng, Yuan, Jigang, Zhu, Zhu, Zou, Xiaoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835956/ https://www.ncbi.nlm.nih.gov/pubmed/29541204 http://dx.doi.org/10.3892/ol.2018.7843

Ejemplares similares

Synergistic Lethality of Mifepristone and LY294002 in Ovarian Cancer Cells
por: Wempe, Stacy L., et al.
Publicado: (2013)

SN50 enhances the effects of LY294002 on cell death induction in gastric cancer cell line SGC7901
por: Zhao, Kui, et al.
Publicado: (2013)

LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II
por: Searl, T. J., et al.
Publicado: (2005)

LY294002 alleviates bone cancer pain by reducing mitochondrial dysfunction and the inflammatory response
por: Zhao, Jiajia, et al.
Publicado: (2023)

Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells
por: Fujiwara, Masao, et al.
Publicado: (2008)

Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
por: Jiang, Hanguo, et al.
Publicado: (2010)

LY294002 induces differentiation and inhibits invasion of glioblastoma cells by targeting GSK-3beta and MMP
por: Tian, Qi, et al.
Publicado: (2012)

Combined low-dose LiCl and LY294002 for the treatment of osteoporosis in ovariectomized rats
por: Bai, Jianhai, et al.
Publicado: (2019)

Effect of Oxaliplatin, Olaparib and LY294002 in Combination on Triple-Negative Breast Cancer Cells
por: Andreidesz, Kitti, et al.
Publicado: (2021)

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002
por: Cai, Xinyi, et al.
Publicado: (2015)

LY294002 Inhibits Intermediate Conductance Calcium-Activated Potassium (KCa3.1) Current in Human Glioblastoma Cells
por: Caglioti, Concetta, et al.
Publicado: (2022)

The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina
por: Rajala, Raju V. S., et al.
Publicado: (2016)

Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect
por: Wiese, Elizabeth K., et al.
Publicado: (2021)

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
por: A, Zając, et al.
Publicado: (2021)

Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin
por: Le, Quoc-Vu, et al.
Publicado: (2022)

Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
por: Linero, Florencia N., et al.
Publicado: (2014)

Encapsulation of PI3K Inhibitor LY294002 within Polymer Nanoparticles Using Ion Pairing Flash Nanoprecipitation
por: Fergusson, Austin D., et al.
Publicado: (2023)

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway
por: Zhao, Penglong, et al.
Publicado: (2020)

LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells
por: Shin, Jung-Young, et al.
Publicado: (2010)

LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1α pathway
por: Xu, Ruyue, et al.
Publicado: (2021)

Autophagy Inhibitor (LY294002) and 5-fluorouracil (5-FU) Combination-Based Nanoliposome for Enhanced Efficacy Against Esophageal Squamous Cell Carcinoma
por: Feng, Ye, et al.
Publicado: (2018)

The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25
por: Duarte, Andressa, et al.
Publicado: (2019)

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
por: Siddiqui, Farid Ahmad, et al.
Publicado: (2018)

Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells
por: Abdallah, Mohamed E., et al.
Publicado: (2020)

Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells
por: Imai, Yasuo, et al.
Publicado: (2012)

Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect
por: Li, Zhen, et al.
Publicado: (2021)

LY294002 Is a Promising Inhibitor to Overcome Sorafenib Resistance in FLT3-ITD Mutant AML Cells by Interfering With PI3K/Akt Signaling Pathway
por: Huang, Amin, et al.
Publicado: (2021)

Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions
por: Bi, Yang-Hui, et al.
Publicado: (2019)

Reversal of the Warburg effect with DCA in PDGF-treated human PASMC is potentiated by pyruvate dehydrogenase kinase-1 inhibition mediated through blocking Akt/GSK-3β signalling
por: Li, Bingbing, et al.
Publicado: (2018)

The role of pyruvate kinase M2 in anticancer therapeutic treatments
por: Su, Qiongli, et al.
Publicado: (2019)

Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo
por: Lu, Jian, et al.
Publicado: (2017)

Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase
por: Luo, Fangxiu, et al.
Publicado: (2019)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
por: Saunier, Elise, et al.
Publicado: (2017)

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
por: Zhao, Xiaoyue, et al.
Publicado: (2018)

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
por: Shankar Babu, Mani, et al.
Publicado: (2018)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex
por: Zhang, Liang, et al.
Publicado: (2021)

The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism
por: Schell, John, et al.
Publicado: (2014)

Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP
por: Choi, Hae-Seul, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4ifjheh6gdm3vt5h0pgiiflajv