Exceptionally high-affinity Ras binders that remodel its effector domain

The Ras proteins are aberrantly activated in a wide range of human cancers, often endowing tumors with aggressive properties and resistance to therapy. Decades of effort to develop direct Ras inhibitors for clinical use have thus far failed, largely because of a lack of adequate small-molecule–bindi...

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Detalles Bibliográficos
Autores principales: McGee, John H., Shim, So Youn, Lee, Seung-Joo, Swanson, Paige K., Jiang, Sam Y., Durney, Michael A., Verdine, Gregory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836121/
https://www.ncbi.nlm.nih.gov/pubmed/29282294
http://dx.doi.org/10.1074/jbc.M117.816348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836121/
https://www.ncbi.nlm.nih.gov/pubmed/29282294
http://dx.doi.org/10.1074/jbc.M117.816348

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