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Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos

BACKGROUND: Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growth hormone and insulin-like growth factor I (IGF-I) pathway and partially res...

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Detalles Bibliográficos
Autores principales: Tsai, Tzu-Chun, Shih, Chun-Che, Chien, Hsin-Ping, Yang, An-Hang, Lu, Jenn-Kan, Lu, Jen-Her
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836385/
https://www.ncbi.nlm.nih.gov/pubmed/29506474
http://dx.doi.org/10.1186/s12861-017-0161-1