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Transcriptional profiling of liver in riboflavin-deficient chicken embryos explains impaired lipid utilization, energy depletion, massive hemorrhaging, and delayed feathering

BACKGROUND: A strain of Leghorn chickens (rd/rd), unable to produce a functional riboflavin-binding protein, lays riboflavin-deficient eggs, in which all embryos suddenly die at mid-incubation (days 13-15). This malady, caused by riboflavin deficiency, leads to excessive lipid accumulation in liver,...

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Detalles Bibliográficos
Autores principales: Cogburn, Larry A., Smarsh, Danielle N., Wang, Xiaofei, Trakooljul, Nares, Carré, Wilfrid, White, Harold B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836443/
https://www.ncbi.nlm.nih.gov/pubmed/29506485
http://dx.doi.org/10.1186/s12864-018-4568-2