MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping

MLL4 is an essential subunit of the H3K4 methylation complexes. We report that MLL4 deficiency compromised regulatory T (T(reg)) cell development and resulted in substantial decreases in H3K4me1 and chromatin interaction at putative enhancers, a remarkable portion of which were not direct targets of...

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Detalles Bibliográficos
Autores principales: Placek, Katarzyna, Hu, Gangqing, Cui, Kairong, Zhang, Dunfang, Ding, Yi, Lee, Ji-Eun, Jang, Younghoon, Wang, Chaochen, Konkel, Joanne Elizabeth, Song, Jiuzhou, Liu, Chengyu, Ge, Kai, Chen, Wanjun, Zhao, Keji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836551/
https://www.ncbi.nlm.nih.gov/pubmed/28759003
http://dx.doi.org/10.1038/ni.3812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836551/
https://www.ncbi.nlm.nih.gov/pubmed/28759003
http://dx.doi.org/10.1038/ni.3812

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