Cargando…

MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping

MLL4 is an essential subunit of the H3K4 methylation complexes. We report that MLL4 deficiency compromised regulatory T (T(reg)) cell development and resulted in substantial decreases in H3K4me1 and chromatin interaction at putative enhancers, a remarkable portion of which were not direct targets of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Placek, Katarzyna, Hu, Gangqing, Cui, Kairong, Zhang, Dunfang, Ding, Yi, Lee, Ji-Eun, Jang, Younghoon, Wang, Chaochen, Konkel, Joanne Elizabeth, Song, Jiuzhou, Liu, Chengyu, Ge, Kai, Chen, Wanjun, Zhao, Keji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836551/ https://www.ncbi.nlm.nih.gov/pubmed/28759003 http://dx.doi.org/10.1038/ni.3812

Ejemplares similares

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
por: Jang, Younghoon, et al.
Publicado: (2019)

Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops
por: Liu, Shuai, et al.
Publicado: (2022)

Marek’s disease virus infection induces widespread differential chromatin marks in inbred chicken lines
por: Mitra, Apratim, et al.
Publicado: (2012)

SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation
por: Kidder, Benjamin L., et al.
Publicado: (2017)

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
por: Northrup, Daniel, et al.
Publicado: (2017)

PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3
por: Zhang, Pin, et al.
Publicado: (2013)

Dynamic regulation of epigenomic landscapes during hematopoiesis
por: Abraham, Brian J, et al.
Publicado: (2013)

Diploid genome architecture revealed by multi-omic data of hybrid mice
por: Han, Zhijun, et al.
Publicado: (2020)

Chromatin looping is needed for iPSC induction
por: Hu, Ji-Fan, et al.
Publicado: (2014)

Landscape of cohesin-mediated chromatin loops in the human genome
por: Grubert, Fabian, et al.
Publicado: (2020)

Group 3 innate lymphoid cells continuously require the transcription factor GATA3 after commitment
por: Zhong, Chao, et al.
Publicado: (2015)

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
por: Lai, Binbin, et al.
Publicado: (2017)

Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq)
por: Carter, Benjamin, et al.
Publicado: (2019)

TGF-β induces ST2 and programs ILC2 development
por: Wang, Li, et al.
Publicado: (2020)

Histone modifications induced by MDV infection at early cytolytic and latency phases
por: Mitra, Apratim, et al.
Publicado: (2015)

Author Correction: Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq)
por: Carter, Benjamin, et al.
Publicado: (2020)

The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias
por: Andersson, Anna K, et al.
Publicado: (2015)

Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia
por: Fung, Juan José, et al.
Publicado: (2015)

Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
por: Shan, Xiaochuan, et al.
Publicado: (2017)

DLoopCaller: A deep learning approach for predicting genome-wide chromatin loops by integrating accessible chromatin landscapes
por: Wang, Siguo, et al.
Publicado: (2022)

Chromatin Loop Extrusion and Chromatin Unknotting
por: Racko, Dusan, et al.
Publicado: (2018)

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells
por: Nakatsukasa, Hiroko, et al.
Publicado: (2015)

Histone Methylation Analysis and Pathway Predictions in Chickens after MDV Infection
por: Luo, Juan, et al.
Publicado: (2012)

LncRNA FOXP4-AS1 Promotes the Progression of Esophageal Squamous Cell Carcinoma by Interacting With MLL2/H3K4me3 to Upregulate FOXP4
por: Niu, Yunfeng, et al.
Publicado: (2021)

Correction: Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
por: Shan, Xiaochuan, et al.
Publicado: (2018)

InferLoop: leveraging single-cell chromatin accessibility for the signal of chromatin loop
por: Zhang, Feng, et al.
Publicado: (2023)

Corrigendum: LncRNA FOXP4-AS1 promotes the progression of esophageal squamous cell carcinoma by interacting with MLL2/H3K4me3 to upregulate FOXP4
por: Niu, Yunfeng, et al.
Publicado: (2022)

Transient T-bet expression functionally specifies a distinct T follicular helper subset
por: Fang, Difeng, et al.
Publicado: (2018)

KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation
por: Kidder, Benjamin L, et al.
Publicado: (2014)

Corrigendum: The conservation and signatures of lincRNAs in Marek’s disease of chicken
por: He, Yanghua, et al.
Publicado: (2016)

The conservation and signatures of lincRNAs in Marek’s disease of chicken
por: He, Yanghua, et al.
Publicado: (2015)

A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development
por: Jani, Anant, et al.
Publicado: (2008)

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
por: Zhang, Yi, et al.
Publicado: (2019)

Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin
por: Bina, Minou, et al.
Publicado: (2013)

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
por: Wang, Rui-Hong, et al.
Publicado: (2016)

Inflammation-induced repression of Foxp3-bound chromatin in regulatory T cells
por: Arvey, Aaron, et al.
Publicado: (2014)

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95
por: Jiang, Hao, et al.
Publicado: (2013)

Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation
por: Kurotaki, Daisuke, et al.
Publicado: (2022)

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
por: Lee, Ji-Eun, et al.
Publicado: (2013)

miR-34a-FOXP1 Loop in Ovarian Cancer
por: Dirimtekin, Esra, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bkjrtkr071g8mgq205r7ib4lfo