Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis

Etrolizumab, a humanized monoclonal antibody, specifically binds to the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. Pharmacokinetic (PK) and pharmacodynamic (PD) data were collected from an etrolizumab phase 1 trial in patients with moderate to severe ulcerative colitis (UC). We develop...

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Detalles Bibliográficos
Autores principales: Wei, Xiaohui, Gibiansky, Leonid, Wang, Yehong, Fuh, Franklin, Erickson, Rich, O'Byrne, Sharon, Tang, Meina T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Modeling and Simulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836964/
https://www.ncbi.nlm.nih.gov/pubmed/29178491
http://dx.doi.org/10.1002/jcph.1031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836964/
https://www.ncbi.nlm.nih.gov/pubmed/29178491
http://dx.doi.org/10.1002/jcph.1031

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