Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation

INTRODUCTION: Fosaprepitant, an intravenous (IV) aprepitant prodrug for chemotherapy-induced nausea and vomiting prophylaxis, is associated with systemic and infusion-site reactions attributed in part to its surfactant, polysorbate 80. HTX-019 is an IV aprepitant formulation free of polysorbate 80 a...

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Detalles Bibliográficos
Autores principales: Ottoboni, Tom, Keller, Mary Rose, Cravets, Matt, Clendeninn, Neil, Quart, Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837372/
https://www.ncbi.nlm.nih.gov/pubmed/29535504
http://dx.doi.org/10.2147/DDDT.S155875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837372/
https://www.ncbi.nlm.nih.gov/pubmed/29535504
http://dx.doi.org/10.2147/DDDT.S155875

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