Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model

Triptolide is a vine extract used in traditional Chinese medicines and associated with hepatotoxicity. In vitro data suggest that inhibition of RNA synthesis may be the mechanism of toxicity. For studying drug-induced liver injury the zebrafish has experimental, practical and financial advantages co...

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Detalles Bibliográficos
Autores principales: Vliegenthart, Adriaan D. Bastiaan, Wei, Chunmin, Buckley, Charlotte, Berends, Cécile, de Potter, Carmelita M. J., Schneemann, Sarah, Del Pozo, Jorge, Tucker, Carl, Mullins, John J., Webb, David J., Dear, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Evaluation of Triptolide Hepatotoxicity in Zebrafish
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837554/
https://www.ncbi.nlm.nih.gov/pubmed/28962522
http://dx.doi.org/10.1093/toxsci/kfx144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837554/
https://www.ncbi.nlm.nih.gov/pubmed/28962522
http://dx.doi.org/10.1093/toxsci/kfx144

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