Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

In amyotrophic lateral sclerosis (ALS) and animal models of ALS, including SOD1-G93A mice, disassembly of the neuromuscular synapse precedes motor neuron loss and is sufficient to cause a decline in motor function that culminates in lethal respiratory paralysis. We treated SOD1-G93A mice with an ago...

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Detalles Bibliográficos
Autores principales: Cantor, Sarah, Zhang, Wei, Delestrée, Nicolas, Remédio, Leonor, Mentis, George Z, Burden, Steven J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837562/
https://www.ncbi.nlm.nih.gov/pubmed/29460776
http://dx.doi.org/10.7554/eLife.34375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837562/
https://www.ncbi.nlm.nih.gov/pubmed/29460776
http://dx.doi.org/10.7554/eLife.34375

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