MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

Targeting the DNA damage response (DDR) in tumors with defective DNA repair is a clinically successful strategy. The RAS/RAF/MEK/ERK signalling pathway is frequently deregulated in human cancers. In this study, we explored the effects of MEK inhibition on the homologous recombination pathway and exp...

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Detalles Bibliográficos
Autores principales: Vena, Francesca, Jia, Ruochen, Esfandiari, Arman, Garcia-Gomez, Juan J., Rodriguez-Justo, Manuel, Ma, Jianguo, Syed, Sakeena, Crowley, Lindsey, Elenbaas, Brian, Goodstal, Samantha, Hartley, John A., Hochhauser, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837749/
https://www.ncbi.nlm.nih.gov/pubmed/29545922
http://dx.doi.org/10.18632/oncotarget.24294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837749/
https://www.ncbi.nlm.nih.gov/pubmed/29545922
http://dx.doi.org/10.18632/oncotarget.24294

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