Architecture of the human mTORC2 core complex

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the...

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Detalles Bibliográficos
Autores principales: Stuttfeld, Edward, Aylett, Christopher HS, Imseng, Stefan, Boehringer, Daniel, Scaiola, Alain, Sauer, Evelyn, Hall, Michael N, Maier, Timm, Ban, Nenad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837792/
https://www.ncbi.nlm.nih.gov/pubmed/29424687
http://dx.doi.org/10.7554/eLife.33101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837792/
https://www.ncbi.nlm.nih.gov/pubmed/29424687
http://dx.doi.org/10.7554/eLife.33101

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