Cargando…

Architecture of the human mTORC2 core complex

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stuttfeld, Edward, Aylett, Christopher HS, Imseng, Stefan, Boehringer, Daniel, Scaiola, Alain, Sauer, Evelyn, Hall, Michael N, Maier, Timm, Ban, Nenad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837792/ https://www.ncbi.nlm.nih.gov/pubmed/29424687 http://dx.doi.org/10.7554/eLife.33101

Ejemplares similares

The 3.2-Å resolution structure of human mTORC2
por: Scaiola, Alain, et al.
Publicado: (2020)

Regulation of human mTOR complexes by DEPTOR
por: Wälchli, Matthias, et al.
Publicado: (2021)

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
por: Arquint, Christian, et al.
Publicado: (2015)

The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism
por: Stanisich, Jessica J, et al.
Publicado: (2020)

A central role for a region in the middle
por: Stuttfeld, Edward, et al.
Publicado: (2017)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

Architecture of the chikungunya virus replication organelle
por: Laurent, Timothée, et al.
Publicado: (2022)

The dynamic organization of fungal acetyl-CoA carboxylase
por: Hunkeler, Moritz, et al.
Publicado: (2016)

Structure of the human BBSome core complex
por: Klink, Björn Udo, et al.
Publicado: (2020)

Structural basis for ion selectivity in TMEM175 K(+) channels
por: Brunner, Janine D, et al.
Publicado: (2020)

The complete structure of the human TFIIH core complex
por: Greber, Basil J, et al.
Publicado: (2019)

Architectural principles for Hfq/Crc-mediated regulation of gene expression
por: Pei, Xue Yuan, et al.
Publicado: (2019)

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement
por: Patel, Avinash B, et al.
Publicado: (2019)

The Ubiquitin-associated (UBA) 1 Domain of Schizosaccharomyces pombe Rhp23 Is Essential for the Recognition of Ubiquitin-proteasome System Substrates Both in Vitro and in Vivo
por: Medina, Bethan, et al.
Publicado: (2012)

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments
por: Barski, Michal, et al.
Publicado: (2017)

Molecular architecture of the yeast Mediator complex
por: Robinson, Philip J, et al.
Publicado: (2015)

Visualizing the functional architecture of the endocytic machinery
por: Picco, Andrea, et al.
Publicado: (2015)

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone
por: Padavannil, Abhilash, et al.
Publicado: (2019)

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
por: Lauer, Janelle, et al.
Publicado: (2019)

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
por: Fei, Xue, et al.
Publicado: (2020)

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
por: Borst, Andrew J, et al.
Publicado: (2018)

Nanoscale protein architecture of the kidney glomerular basement membrane
por: Suleiman, Hani, et al.
Publicado: (2013)

Molecular architecture of human polycomb repressive complex 2
por: Ciferri, Claudio, et al.
Publicado: (2012)

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
por: Baskaran, Sulochanadevi, et al.
Publicado: (2014)

Molecular architecture of the 90S small subunit pre-ribosome
por: Sun, Qi, et al.
Publicado: (2017)

Characterization of the Molecular Architecture of Human Caveolin-3 and Interaction with the Skeletal Muscle Ryanodine Receptor
por: Whiteley, Gareth, et al.
Publicado: (2012)

mTORC1 Enhances Early Phase Ribosome Processivity
por: An, Erin, et al.
Publicado: (2020)

Correction: Nanoscale protein architecture of the kidney glomerular basement membrane
por: Suleiman, Hani, et al.
Publicado: (2013)

Correction: Molecular architecture of the 90S small subunit pre-ribosome
por: Sun, Qi, et al.
Publicado: (2017)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
por: Fei, Xue, et al.
Publicado: (2020)

Polydisperse molecular architecture of connexin 26/30 heteromeric hemichannels revealed by atomic force microscopy imaging
por: Naulin, Pamela A., et al.
Publicado: (2021)

Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography
por: Engel, Benjamin D, et al.
Publicado: (2015)

Structural basis for the reaction cycle of DASS dicarboxylate transporters
por: Sauer, David B, et al.
Publicado: (2020)

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding
por: Bewley, Maria C., et al.
Publicado: (2021)

Correction: Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography
por: Engel, Benjamin D, et al.
Publicado: (2015)

Binary architecture of the Na(v)1.2-β2 signaling complex
por: Das, Samir, et al.
Publicado: (2016)

Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin
por: Bookwalter, Carol S., et al.
Publicado: (2017)

Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex
por: Erzberger, Jan P., et al.
Publicado: (2014)

Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex
por: Erzberger, Jan P., et al.
Publicado: (2014)

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
por: Mitrea, Diana M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_02cg7p1mviupm6ltvd9c5jeuvg