Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are pathogenic for familial Parkinson’s disease. However, it is unknown whether levels of LRRK2 protein in the brain are altered in patients with LRRK2-associated Parkinson’s disease. Because LRRK2 mutations are relatively rare, accounting f...

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Detalles Bibliográficos
Autores principales: Zhao, Ye, Perera, Gayathri, Takahashi-Fujigasaki, Junko, Mash, Deborah C, Vonsattel, Jean Paul G, Uchino, Akiko, Hasegawa, Kazuko, Jeremy Nichols, R, Holton, Janice L, Murayama, Shigeo, Dzamko, Nicolas, Halliday, Glenda M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837795/
https://www.ncbi.nlm.nih.gov/pubmed/29253086
http://dx.doi.org/10.1093/brain/awx344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837795/
https://www.ncbi.nlm.nih.gov/pubmed/29253086
http://dx.doi.org/10.1093/brain/awx344

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