Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory

Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and inhibition, is found in patients with mild cognitive impairment, a prodromal stage of Alzheimer's disease (AD). To better understand the relationship between hippocampal hyperactivity and the molec...

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Detalles Bibliográficos
Autores principales: Yoshikawa, Misato, Soeda, Yoshiyuki, Michikawa, Makoto, Almeida, Osborne F. X., Takashima, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838015/
https://www.ncbi.nlm.nih.gov/pubmed/29545742
http://dx.doi.org/10.3389/fnins.2018.00124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838015/
https://www.ncbi.nlm.nih.gov/pubmed/29545742
http://dx.doi.org/10.3389/fnins.2018.00124

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