Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors

Under homeostatic conditions the release of self-RNA from dying cells does not promote inflammation. However, following injury or inflammatory skin diseases such as psoriasis and rosacea, expression of the cathelicidin antimicrobial peptide LL37 breaks tolerance to self-nucleic acids and triggers in...

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Detalles Bibliográficos
Autores principales: Takahashi, Toshiya, Kulkarni, Nikhil Nitin, Lee, Ernest Y, Zhang, Ling-juan, Wong, Gerard C. L., Gallo, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838106/
https://www.ncbi.nlm.nih.gov/pubmed/29507358
http://dx.doi.org/10.1038/s41598-018-22409-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838106/
https://www.ncbi.nlm.nih.gov/pubmed/29507358
http://dx.doi.org/10.1038/s41598-018-22409-3

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