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Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors
Under homeostatic conditions the release of self-RNA from dying cells does not promote inflammation. However, following injury or inflammatory skin diseases such as psoriasis and rosacea, expression of the cathelicidin antimicrobial peptide LL37 breaks tolerance to self-nucleic acids and triggers in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838106/ https://www.ncbi.nlm.nih.gov/pubmed/29507358 http://dx.doi.org/10.1038/s41598-018-22409-3 |