Lack of metabolism in (R)-ketamine’s antidepressant actions in a chronic social defeat stress model

Since the metabolism of (R,S)-ketamine to (2R,6R)-hydroxynorketamine (HNK) is reported to be essential for ketamine’s antidepressant effects, there is an increasing debate about antidepressant effects of (2R,6R)-HNK. Using pharmacokinetic and behavioral techniques, we investigated whether intracereb...

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Detalles Bibliográficos
Autores principales: Zhang, Kai, Fujita, Yuko, Hashimoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838158/
https://www.ncbi.nlm.nih.gov/pubmed/29507385
http://dx.doi.org/10.1038/s41598-018-22449-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838158/
https://www.ncbi.nlm.nih.gov/pubmed/29507385
http://dx.doi.org/10.1038/s41598-018-22449-9

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