Cargando…
Lack of metabolism in (R)-ketamine’s antidepressant actions in a chronic social defeat stress model
Since the metabolism of (R,S)-ketamine to (2R,6R)-hydroxynorketamine (HNK) is reported to be essential for ketamine’s antidepressant effects, there is an increasing debate about antidepressant effects of (2R,6R)-HNK. Using pharmacokinetic and behavioral techniques, we investigated whether intracereb...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838158/ https://www.ncbi.nlm.nih.gov/pubmed/29507385 http://dx.doi.org/10.1038/s41598-018-22449-9 |