Cargando…

DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins

Cell-to-cell transmission of misfolded proteins propagates proteotoxic stress in multicellular organisms when transmitted polypeptides serve as a seeding template to cause protein misfolding in recipient cells, but how misfolded proteins are released from cells to initiate this process is unclear. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Yue, Cui, Lei, Dibello, Anthony, Wang, Lihui, Lee, Juhyung, Saidi, Layla, Lee, Jin-Gu, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838229/
https://www.ncbi.nlm.nih.gov/pubmed/29531792
http://dx.doi.org/10.1038/s41421-018-0012-7