Cargando…
DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins
Cell-to-cell transmission of misfolded proteins propagates proteotoxic stress in multicellular organisms when transmitted polypeptides serve as a seeding template to cause protein misfolding in recipient cells, but how misfolded proteins are released from cells to initiate this process is unclear. M...
Autores principales: | Xu, Yue, Cui, Lei, Dibello, Anthony, Wang, Lihui, Lee, Juhyung, Saidi, Layla, Lee, Jin-Gu, Ye, Yihong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838229/ https://www.ncbi.nlm.nih.gov/pubmed/29531792 http://dx.doi.org/10.1038/s41421-018-0012-7 |
Ejemplares similares
-
Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation
por: Lee, Juhyung, et al.
Publicado: (2022) -
Safeguarding Lysosomal Homeostasis by DNAJC5/CSPα-Mediated Unconventional Protein Secretion and Endosomal Microautophagy
por: Lee, Juhyung, et al.
Publicado: (2022) -
The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
por: Jung, Jinsei, et al.
Publicado: (2016) -
The Roles of Endo-Lysosomes in Unconventional Protein Secretion
por: Lee, Juhyung, et al.
Publicado: (2018) -
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers
por: Wu, Shenjie, et al.
Publicado: (2023)