Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model

AIM: To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout (Fah(-/-)) mice by homologous-recombination-mediated targeted addition of the Fah gene. METHODS: C57BL/6 Fah(∆exon5) mice served as an animal model for human tyrosinaemia type 1 in our study. The ve...

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Detalles Bibliográficos
Autores principales: Junge, Norman, Yuan, Qinggong, Vu, Thu Huong, Krooss, Simon, Bednarski, Christien, Balakrishnan, Asha, Cathomen, Toni, Manns, Michael P, Baumann, Ulrich, Sharma, Amar Deep, Ott, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838446/
https://www.ncbi.nlm.nih.gov/pubmed/29527263
http://dx.doi.org/10.4254/wjh.v10.i2.277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838446/
https://www.ncbi.nlm.nih.gov/pubmed/29527263
http://dx.doi.org/10.4254/wjh.v10.i2.277

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