A Rational Active-Site Redesign Converts a Decarboxylase into a C=C Hydratase: “Tethered Acetate” Supports Enantioselective Hydration of 4-Hydroxystyrenes

[Image: see text] The promiscuous regio- and stereoselective hydration of 4-hydroxystyrenes catalyzed by ferulic acid decarboxylase from Enterobacter sp. (FDC_Es) depends on bicarbonate bound in the active site, which serves as a proton relay activating a water molecule for nucleophilic attack on a...

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Detalles Bibliográficos
Autores principales: Payer, Stefan E., Pollak, Hannah, Glueck, Silvia M., Faber, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838639/
https://www.ncbi.nlm.nih.gov/pubmed/29527405
http://dx.doi.org/10.1021/acscatal.7b04293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838639/
https://www.ncbi.nlm.nih.gov/pubmed/29527405
http://dx.doi.org/10.1021/acscatal.7b04293

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