RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs

BACKGROUND: There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by bronchial epithelial cell (BEC) expression patterns...

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Detalles Bibliográficos
Autores principales: Yeo, Jiyoun, Morales, Diego A., Chen, Tian, Crawford, Erin L., Zhang, Xiaolu, Blomquist, Thomas M., Levin, Albert M., Massion, Pierre P., Arenberg, Douglas A., Midthun, David E., Mazzone, Peter J., Nathan, Steven D., Wainz, Ronald J., Nana-Sinkam, Patrick, Willey, Paige F. S., Arend, Taylor J., Padda, Karanbir, Qiu, Shuhao, Federov, Alexei, Hernandez, Dawn-Alita R., Hammersley, Jeffrey R., Yoon, Youngsook, Safi, Fadi, Khuder, Sadik A., Willey, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838965/
https://www.ncbi.nlm.nih.gov/pubmed/29506519
http://dx.doi.org/10.1186/s12890-018-0603-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838965/
https://www.ncbi.nlm.nih.gov/pubmed/29506519
http://dx.doi.org/10.1186/s12890-018-0603-y

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