Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex

PTF1 complex is critical for pancreatic development and maintenance of adult exocrine pancreas. As a part of our ongoing studies to identify genetic variation that contributes to type 2 diabetes (T2D) in American Indians, we analyzed variation in genes that form this complex, namely PTF1A, RBPJ, and...

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Detalles Bibliográficos
Autores principales: Nair, Anup K., Sutherland, Jeff R., Traurig, Michael, Piaggi, Paolo, Chen, Peng, Kobes, Sayuko, Hanson, Robert L., Bogardus, Clifton, Baier, Leslie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839029/
https://www.ncbi.nlm.nih.gov/pubmed/29302047
http://dx.doi.org/10.1038/s41431-017-0062-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839029/
https://www.ncbi.nlm.nih.gov/pubmed/29302047
http://dx.doi.org/10.1038/s41431-017-0062-6

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