Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo loading during selective autophagy. Here we show that the expre...

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Detalles Bibliográficos
Autores principales: Ehrnhoefer, Dagmar E., Martin, Dale D. O., Schmidt, Mandi E., Qiu, Xiaofan, Ladha, Safia, Caron, Nicholas S., Skotte, Niels H., Nguyen, Yen T. N., Vaid, Kuljeet, Southwell, Amber L., Engemann, Sabine, Franciosi, Sonia, Hayden, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839066/
https://www.ncbi.nlm.nih.gov/pubmed/29510748
http://dx.doi.org/10.1186/s40478-018-0518-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839066/
https://www.ncbi.nlm.nih.gov/pubmed/29510748
http://dx.doi.org/10.1186/s40478-018-0518-0

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