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A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration

PURPOSE: To develop an animal behavioral assay for the quantitative assessment of the functional efficacy of optogenetic therapies. METHODS: A triple-knockout (TKO) mouse line, Gnat1(−/−)Cnga3(−/−)Opn4(−/−), and a double-knockout mouse line, Gnat1(−/−)Cnga3(−/−), were employed. The expression of cha...

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Detalles Bibliográficos
Autores principales: Lu, Qi, Ganjawala, Tushar H., Hattar, Samer, Abrams, Gary W., Pan, Zhuo-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839255/
https://www.ncbi.nlm.nih.gov/pubmed/29625451
http://dx.doi.org/10.1167/iovs.17-23278