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A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration
PURPOSE: To develop an animal behavioral assay for the quantitative assessment of the functional efficacy of optogenetic therapies. METHODS: A triple-knockout (TKO) mouse line, Gnat1(−/−)Cnga3(−/−)Opn4(−/−), and a double-knockout mouse line, Gnat1(−/−)Cnga3(−/−), were employed. The expression of cha...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839255/ https://www.ncbi.nlm.nih.gov/pubmed/29625451 http://dx.doi.org/10.1167/iovs.17-23278 |