Potent anti-tumor activity of a syringolin analog in multiple myeloma: a dual inhibitor of proteasome activity targeting β2 and β5 subunits

Proteasome inhibitors (PI), mainly targeting the β5 subunit of the 20S proteasome, are widely used in the treatment of multiple myeloma (MM). However, PI resistance remains an unresolved problem in the therapy of relapsed and refractory MM. To develop a new PI that targets other proteasome subunits,...

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Detalles Bibliográficos
Autores principales: Yoshida, Takashi, Ri, Masaki, Kanamori, Takashi, Aoki, Sho, Ashour, Reham, Kinoshita, Shiori, Narita, Tomoko, Totani, Haruhito, Masaki, Ayako, Ito, Asahi, Kusumoto, Shigeru, Ishida, Takashi, Komatsu, Hirokazu, Kitahata, Shun, Chiba, Takuya, Ichikawa, Satoshi, Iida, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839415/
https://www.ncbi.nlm.nih.gov/pubmed/29515784
http://dx.doi.org/10.18632/oncotarget.24160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839415/
https://www.ncbi.nlm.nih.gov/pubmed/29515784
http://dx.doi.org/10.18632/oncotarget.24160

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