Critical domain interactions for type A RNase P RNA catalysis with and without the specificity domain

The natural trans-acting ribozyme RNase P RNA (RPR) is composed of two domains in which the catalytic (C-) domain mediates cleavage of various substrates. The C-domain alone, after removal of the second specificity (S-) domain, catalyzes this reaction as well, albeit with reduced efficiency. Here we...

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Detalles Bibliográficos
Autores principales: Mao, Guanzhong, Srivastava, Abhishek S., Wu, Shiying, Kosek, David, Lindell, Magnus, Kirsebom, Leif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839562/
https://www.ncbi.nlm.nih.gov/pubmed/29509761
http://dx.doi.org/10.1371/journal.pone.0192873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839562/
https://www.ncbi.nlm.nih.gov/pubmed/29509761
http://dx.doi.org/10.1371/journal.pone.0192873

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