Tissue-specific and mosaic imprinting defects underlie opposite congenital growth disorders in mice

Differential DNA methylation defects of H19/IGF2 are associated with congenital growth disorders characterized by opposite clinical pictures. Due to structural differences between human and mouse, the mechanisms by which mutations of the H19/IGF2 Imprinting Control region (IC1) result in these disea...

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Detalles Bibliográficos
Autores principales: Freschi, Andrea, Hur, Stella K., Valente, Federica Maria, Ideraabdullah, Folami Y., Sparago, Angela, Gentile, Maria Teresa, Oneglia, Andrea, Di Nucci, Diego, Colucci-D’Amato, Luca, Thorvaldsen, Joanne L., Bartolomei, Marisa S., Riccio, Andrea, Cerrato, Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839592/
https://www.ncbi.nlm.nih.gov/pubmed/29470501
http://dx.doi.org/10.1371/journal.pgen.1007243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839592/
https://www.ncbi.nlm.nih.gov/pubmed/29470501
http://dx.doi.org/10.1371/journal.pgen.1007243

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