Coarse-grained molecular dynamics simulations reveal lipid access pathways in P-glycoprotein

P-glycoprotein (P-gp) exports a broad range of dissimilar compounds, including drugs, lipids, and lipid-like molecules. Because of its substrate promiscuity, P-gp is a key player in the development of cancer multidrug resistance. Although P-gp is one of the most studied ABC transporters, the mechani...

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Detalles Bibliográficos
Autores principales: Barreto-Ojeda, Estefania, Corradi, Valentina, Gu, Ruo-Xu, Tieleman, D. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839720/
https://www.ncbi.nlm.nih.gov/pubmed/29437858
http://dx.doi.org/10.1085/jgp.201711907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839720/
https://www.ncbi.nlm.nih.gov/pubmed/29437858
http://dx.doi.org/10.1085/jgp.201711907

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