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Stac3 enhances expression of human Ca(V)1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels

Mutations of Ca(V)1.1, the pore-forming subunit of the L-type Ca(2+) channel in skeletal muscle, are an established cause of hypokalemic periodic paralysis (HypoPP). However, functional assessment of HypoPP mutant channels has been hampered by difficulties in achieving sufficient plasma membrane exp...

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Detalles Bibliográficos
Autores principales: Wu, Fenfen, Quinonez, Marbella, DiFranco, Marino, Cannon, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839724/
https://www.ncbi.nlm.nih.gov/pubmed/29386226
http://dx.doi.org/10.1085/jgp.201711962