PTEN negatively regulates the cell lineage progression from NG2(+) glial progenitor to oligodendrocyte via mTOR-independent signaling

Oligodendrocytes (OLs), the myelin-forming CNS glia, are highly vulnerable to cellular stresses, and a severe myelin loss underlies numerous CNS disorders. Expedited OL regeneration may prevent further axonal damage and facilitate functional CNS repair. Although adult OL progenitors (OPCs) are the p...

Descripción completa

Detalles Bibliográficos
Autores principales: González-Fernández, Estibaliz, Jeong, Hey-Kyeong, Fukaya, Masahiro, Kim, Hyukmin, Khawaja, Rabia R, Srivastava, Isha N, Waisman, Ari, Son, Young-Jin, Kang, Shin H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839742/
https://www.ncbi.nlm.nih.gov/pubmed/29461205
http://dx.doi.org/10.7554/eLife.32021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839742/
https://www.ncbi.nlm.nih.gov/pubmed/29461205
http://dx.doi.org/10.7554/eLife.32021

Ejemplares similares