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PTEN negatively regulates the cell lineage progression from NG2(+) glial progenitor to oligodendrocyte via mTOR-independent signaling

Oligodendrocytes (OLs), the myelin-forming CNS glia, are highly vulnerable to cellular stresses, and a severe myelin loss underlies numerous CNS disorders. Expedited OL regeneration may prevent further axonal damage and facilitate functional CNS repair. Although adult OL progenitors (OPCs) are the p...

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Detalles Bibliográficos
Autores principales:	González-Fernández, Estibaliz, Jeong, Hey-Kyeong, Fukaya, Masahiro, Kim, Hyukmin, Khawaja, Rabia R, Srivastava, Isha N, Waisman, Ari, Son, Young-Jin, Kang, Shin H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839742/ https://www.ncbi.nlm.nih.gov/pubmed/29461205 http://dx.doi.org/10.7554/eLife.32021

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