Deficiency in T follicular regulatory cells promotes autoimmunity

T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6(fl/fl)Foxp3Cre mouse to analyze the funct...

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Autores principales: Fu, Weiwei, Liu, Xindong, Lin, Xiang, Feng, Han, Sun, Lin, Li, Shuran, Chen, Hairong, Tang, Hong, Lu, Liwei, Jin, Wei, Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839755/
https://www.ncbi.nlm.nih.gov/pubmed/29378778
http://dx.doi.org/10.1084/jem.20170901
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author Fu, Weiwei
Liu, Xindong
Lin, Xiang
Feng, Han
Sun, Lin
Li, Shuran
Chen, Hairong
Tang, Hong
Lu, Liwei
Jin, Wei
Dong, Chen
author_facet Fu, Weiwei
Liu, Xindong
Lin, Xiang
Feng, Han
Sun, Lin
Li, Shuran
Chen, Hairong
Tang, Hong
Lu, Liwei
Jin, Wei
Dong, Chen
author_sort Fu, Weiwei
collection PubMed
description T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6(fl/fl)Foxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6(fl/fl)Foxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjögren’s syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6(fl/fl)Cd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease.
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spelling pubmed-58397552018-09-05 Deficiency in T follicular regulatory cells promotes autoimmunity Fu, Weiwei Liu, Xindong Lin, Xiang Feng, Han Sun, Lin Li, Shuran Chen, Hairong Tang, Hong Lu, Liwei Jin, Wei Dong, Chen J Exp Med Research Articles T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6(fl/fl)Foxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6(fl/fl)Foxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjögren’s syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6(fl/fl)Cd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease. Rockefeller University Press 2018-03-05 /pmc/articles/PMC5839755/ /pubmed/29378778 http://dx.doi.org/10.1084/jem.20170901 Text en © 2018 Fu et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Fu, Weiwei
Liu, Xindong
Lin, Xiang
Feng, Han
Sun, Lin
Li, Shuran
Chen, Hairong
Tang, Hong
Lu, Liwei
Jin, Wei
Dong, Chen
Deficiency in T follicular regulatory cells promotes autoimmunity
title Deficiency in T follicular regulatory cells promotes autoimmunity
title_full Deficiency in T follicular regulatory cells promotes autoimmunity
title_fullStr Deficiency in T follicular regulatory cells promotes autoimmunity
title_full_unstemmed Deficiency in T follicular regulatory cells promotes autoimmunity
title_short Deficiency in T follicular regulatory cells promotes autoimmunity
title_sort deficiency in t follicular regulatory cells promotes autoimmunity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839755/
https://www.ncbi.nlm.nih.gov/pubmed/29378778
http://dx.doi.org/10.1084/jem.20170901
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