Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

Alzheimer’s disease (AD) is a neurodegenerative disease that causes late-onset dementia. The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide association studies. In mouse AD models, TREM2-deficient microglia fail to proliferate and cluster around the amyloid-β plaques ch...

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Detalles Bibliográficos
Autores principales: Song, Wilbur M., Joshita, Satoru, Zhou, Yingyue, Ulland, Tyler K., Gilfillan, Susan, Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839761/
https://www.ncbi.nlm.nih.gov/pubmed/29321225
http://dx.doi.org/10.1084/jem.20171529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839761/
https://www.ncbi.nlm.nih.gov/pubmed/29321225
http://dx.doi.org/10.1084/jem.20171529

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