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Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
Alzheimer’s disease (AD) is a neurodegenerative disease that causes late-onset dementia. The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide association studies. In mouse AD models, TREM2-deficient microglia fail to proliferate and cluster around the amyloid-β plaques ch...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839761/ https://www.ncbi.nlm.nih.gov/pubmed/29321225 http://dx.doi.org/10.1084/jem.20171529 |